Numerical study of time-fractional fourth-order differential equations with variable coefficients

AbstractIn this article, we study numerical solutions of time-fractional fourth-order partial differential equations with variable coefficients by introducing the fractional derivative in the sense of Caputo. We implement reliable series solution techniques namely Adomian decomposition method (ADM) and He’s variational iteration method (HVIM). Some applications are presented to highlight the significant features of these techniques. The comparison shows that the solutions obtained are in good agreement with each other and with their respective exact solutions. Some of these types of differential equations arise practically in the theory of transverse vibrations

Secondary Fahr’s Disease: A Consequence of Post-Thyroidectomy Hypoparathyroidism

Objective: The objective of this case report is to emphasize the importance of considering uncommon conditions like Fahr’s disease in the differential diagnosis of seizures and cognitive impairment, especially in patients with a history of thyroidectomy. Material and Methods: A 56-year-old woman who had undergone subtotal thyroidectomy 25 years previously presented with movement disorder and cognitive impairment secondary to hypoparathyroidism. A CT scan of the brain showed pathognomonic bilateral calcification in the basal ganglia, thalamus and cerebellar nuclei. Result: The patient was diagnosed with Fahr’s disease caused by post-thyroidectomy hypoparathyroidism and successfully managed with oral calcium, carbidopa/levodopa and haloperidol. Conclusion: We recommend the routine use of CT scanning in the long-term follow-up of post-thyroidectomy patients

Correlation of red cell distribution width with inflammatory markers and its prognostic value in patients with diabetes and coronary artery disease

Background. Recent studies have shown red blood cell distribution width (RDW) as a marker for severity and prognosis in coronary artery disease patients. Other studies have also correlated RDW with diabetes mellitus and inflammation. However, such correlation and prognosis in patients with concomitant coronary artery disease and diabetes after percutaneous intervention remains unclear. Material and methods. Our study group comprised of 730 subjects including 700 patients (cases) and 30 normal subjects (control group). Patients who presented with coronary artery disease were divided into diabetic and non-diabetic groups. All patients had RDW measured at admission and percutaneous intervention was done. Follow-up for adverse events was carried out between 6 to 12 months. Results. RDW was elevated in patients as compared to control group (p < 0.05). RDW correlated well with inflammatory markers including erythrocyte sedimen­tation rate, C-reactive protein, HbA1c, white blood cells and troponin. RDW was higher with more severe atherosclerosis based on SYNTAX and Gensini scores (p < 0.05). Prognosis was found to be worse in patients with high RDW as well as in diabetics. Conclusions. RDW has positive correlation with other inflammatory marker. It may be used as a marker in determining the severity and prognosis in diabetic patients with coronary artery disease

The Impact and Implications of ISO Certification on Patient Satisfaction-A Single-Centre Study.

Objective: To examine the impact of the international organization for standardization (ISO), the challenges faced in its implementation and the implications of the process on patient care in the long-term accreditation in a tertiary care hospital in Kharian. Study Design: Cross-Sectional Study Place and Duration of Study: Combined Military Hospital, Kharian Pakistan, from Jan to Dec 2019. Methodology: Patient satisfaction questionnaires were given to 1600 patients presenting to the Indoor, Outdoor, Accidents & Emergency, Pharmacy, Radiology Department and Laboratory of Combined Military Hospital, Kharian Pakistan, as a part of a routine ISO audit annually for 2019. Responses were analyzed and tabulated. Results: The upward trend in patient satisfaction was attributed to administrative intervention policies based on patient complaints and suggestions incorporated into the questionnaires’ comment boxes. There was a significant difference between the response rates of patients in departments (p=0.016). It indicates that the satisfaction rate was higher among different departments. Conclusion: Patient satisfaction is directly proportional to interventional measures based on patient feedback. When utilised positively, these feedback loops can lead to an increase in the hospital's overall efficiency index and the standard of care

Technical investigation on V2G, S2V, and V2I for next generation smart city planning

The paper investigates a few of the major areas of the next generation technological advancement, “smart city planning concept”. The areas that the paper focuses are vehicle to grid (V2G), sun to vehicle (S2V), and vehicle to infrastructure (V2I). For the bi-directional crowd energy single entity concept, V2G and building to grid (B2G) are the primary parts of distributed renewable generation (DRG) under smart living. This research includes an in-depth overview of this three major areas. Next, the research conducts a case analysis of V2G, S2V, and V2I along with their possible limitations in order to find out the novel solutions for future development both for academia and industry levels. Lastly, few possible solutions have been proposed to minimize the limitations and to develop the existing system for future expansion

Drought Susceptibility Index; a Preferred Criterion in Screening for Tolerance in Soybean

Soybean (Glycine max L.) yield and yield related traits are constrained by drought. Adaptation of soybean to changing environment could be improved by exploitation and introgression of diverse germplasm in breeding program. In present study, the response to drought conditions, especially at flowering stage, was evaluated to determine the potential soybean germplasm for future soybean breeding programs in Pakistan. Field experiment was conducted under two water regimes i.e. well-water and water-limited, to assess the effect of drought in seed yield and yield related traits. Although, drought led to overall reduction of ~15 % in thousand seed weight but still some soybean genotypes performed relatively better under water-limited conditions. These genotypes were also tolerant to drought, with a drought susceptibility index of \u3c 0.5. PCA also explained the pattern of variation existing in soybean germplasm grown under given water regimes i.e. well-water and water-limited conditions. The identified soybean genotypes could be a favorable resource to introduce high yielding soybean in local environment

Effect of slow-release nitrogenous fertilizers on dry matter accumulation, grain nutritional quality, water productivity and wheat yield under an arid environment

Slow release nitrogenous fertilizers can improve crops production and reduce the environmental challenges in agro-ecosystem. There is a need to test the efficiency and performance under arid climatic conditions. The study investigates the effect of slow-release fertilizers (urea, neem coated urea (NCU), sulfur coated urea (SCU) and bioactive sulfur coated urea (BSCU)) on the growth, productivity and grain nutritional qualities of wheat crop. Slow-release fertilizers (SRF) with nitrogen levels (130,117,104 and 94 kg ha−1) were applied with equal splits at sowing, 20 and 60 days after sowing (DAS). Research showed that the BSCU with 130 kg ha−1 increased dry matter accumulation (1989 kg ha−1) after anthesis and grain yield 4463 kg ha−1. The higher plant height (102 cm) was attained by 130 kg N ha−1 SCU while the minimum (77.67 cm) recorded for 94 kg N ha−1 as urea source. Maximum grain NPK concentrations (3.54, 0.66 and 1.07%) were recorded by BSCU 130 kg N ha−1 application. While, the minimum NPK (0.77, 0.19 and 0.35%) were observed by Urea 94 kg N ha−1. The high irrigation water use efficiency (WUE) recorded (20.92 kg ha−1 mm−1) and a crop index of 25.52% by BSCU 130 kg N ha−1 application. Research findings show that generally all SRF but particularly BSCU proved effective and can be recommended for wheat crop under arid environmen

Prognostic significance of serum potassium level for major adverse cardiac events and death in patients with coronary atherosclerotic disease

Introduction: Serum potassium levels have been shown in some animal studies to be associated with theprocess of atherosclerosis. We decided to assess the correlation of serum potassium level in ischemic heart diseasepatients with disease severity and its relationship with prognosis in terms of major acute cardiac events (MACE). Material and methods: This was a cross-sectional cohort study carried out at cardiology department of RehmanMedical Institute, from July 2016 to 31st Aug. 2018 a period of 26 months. 622 patients were included in thestudy. Clinical and angiographic characteristics were assessed based on the serum potassium level. Correlation ofserum potassium level with Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery(SYNTAX) and Gensini scores was also evaluated. Follow up for MACE was carried out after one year. Results: Mean serum potassium level was 3.93 ± 0.95 (mEq/l) in coronary artery disease patients. Serumpotassium level showed negative correlation with SYNTAX score (r = –0.60, p < 0.05) and Gensini score(r = –0.64, p < 0.05). There was also a significant difference between low and high potassium level in relationto the multi-vessel disease on coronary angiography (p < 0.05). Low potassium level was a good predictor ofadverse outcomes as shown by Kaplan-Meier analysis. Multivariate Cox regression analysis showed that serumpotassium level and diabetes were independent predictors of MACE (p < 0.05). Conclusion: Low serum potassium level is correlated with more severe coronary atherosclerosis. Low potassiumlevels are associated with significantly poor outcomes

Latency reduction by dynamic channel estimator selection in C-RAN networks using fuzzy logic

Due to a dramatic increase in the number of mobile users, operators are forced to expand their networks accordingly. Cloud Radio Access Network (C-RAN) was introduced to tackle the problems of the current generation of mobile networks and to support future 5G networks. However, many challenges have arisen through the centralised structure of C-RAN. The accuracy of the channel state information acquisition in the C-RAN for large numbers of remote radio heads and user equipment is one of the main challenges in this architecture. In order to minimize the time required to acquire the channel information in C-RAN and to reduce the end-to-end latency, in this paper a dynamic channel estimator selection algorithm is proposed. The idea is to assign different channel estimation algorithms to the users of mobile networks based on their link status (particularly the SNR threshold). For the purpose of automatic and adaptive selection to channel estimators, a fuzzy logic algorithm is employed as a decision maker to select the best SNR threshold by utilising the bit error rate measurements. The results demonstrate a reduction in the estimation time with low loss in data throughput. It is also observed that the outcome of the proposed algorithm increases at high SNR values

Biallelic Variants in Seven Different Genes Associated with Clinically Suspected Bardet-Biedl Syndrome

Bardet-Biedl syndrome (BBS) is a rare clinically and genetically heterogeneous autosomal recessive multi-systemic disorder with 22 known genes. The primary clinical and diagnostic features include six different hallmarks, such as rod-cone dystrophy, learning difficulties, renal abnormalities, male hypogonadism, post-axial polydactyly, and obesity. Here, we report nine consanguineous families and a non-consanguineous family with several affected individuals presenting typical clinical features of BBS. In the present study, 10 BBS Pakistani families were subjected to whole exome sequencing (WES), which revealed novel/recurrent gene variants, including a homozygous nonsense mutation (c.94C>T; p.Gln32Ter) in the IFT27 (NM_006860.5) gene in family A, a homozygous nonsense mutation (c.160A>T; p.Lys54Ter) in the BBIP1 (NM_001195306.1) gene in family B, a homozygous nonsense variant (c.720C>A; p.Cys240Ter) in the WDPCP (NM_015910.7) in family C, a homozygous nonsense variant (c.505A>T; p.Lys169Ter) in the LZTFL1 (NM_020347.4) in family D, pathogenic homozygous 1 bp deletion (c.775delA; p.Thr259Leufs*21) in the MKKS/BBS5 (NM_170784.3) gene in family E, a pathogenic homozygous missense variant (c.1339G>A; p.Ala447Thr) in BBS1 (NM_024649.4) in families F and G, a pathogenic homozygous donor splice site variant (c.951+1G>A; p?) in BBS1 (NM_024649.4) in family H, a pathogenic bi-allelic nonsense variant in MKKS (NM_170784.3) (c.119C>G; p.Ser40*) in family I, and homozygous pathogenic frameshift variants (c.196delA; p.Arg66Glufs*12) in BBS5 (NM_152384.3) in family J. Our findings extend the mutation and phenotypic spectrum of four different types of ciliopathies causing BBS and also support the importance of these genes in the development of multi-systemic human genetic disorders